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Papers of the Week


Papers: 18 Jan 2025 - 24 Jan 2025


2025 Jan 20


Psychopharmacology (Berl)


39832015

D1 dopamine / mu opioid receptor interactions in operant conditioning assays of pain-depressed responding and drug-induced rate suppression, and a conditioned place preference procedure: assessment of therapeutic index in male Sprague Dawley rats.

Authors

LaCourse H, Bennett L, Falstad A, Asmus F, Smith M, Davis R, Harrington K, Giuvelis D, King T, Stevenson GW

Abstract

In vivo receptor interactions vary as a function of behavioral endpoint, with key differences between reflexive and non-reflexive measures that assess the motivational aspects of pain and pain relief. There have been no assessments of D dopamine agonist / mu opioid receptor (MOR) agonist interactions in non-reflexive behavioral measures of pain. We examined the hypothesis that D/MOR mixtures show enhanced effectiveness in blocking pain depressed behaviors while showing decreased side effects such as sedation and drug reward.