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Papers of the Week

Papers: 11 May 2024 - 17 May 2024

2024 May 14

Hormones (Athens)


Corticotropin-releasing hormone deficiency results in impaired analgesic response during CFA-induced inflammation.


Karagianni E, Rassouli O, Poulaki S, Dermitzaki E, Liapakis G, Margioris AN, Venihaki M


Corticotropin-releasing hormone (CRH) plays an important role in relief of pain by releasing analgesia-associated molecules in several inflammatory states. During inflammation, peripheral CRH acts on cells of the immune system to stimulate the local expression of proopiomelanocortin (POMC) and the production of β-endorphin, which in turn binds to opioid receptors on sensory neurons to produce antinociception. In the present study, we further investigated the role of endogenous CRH in inflammatory pain by determining the effects of Crh-deficiency on this process.