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Papers of the Week


Papers: 12 Aug 2023 - 18 Aug 2023

RESEARCH TYPE:
Basic Science, Psychology


Animal Studies, Genetics, Molecular/Cellular, Neurobiology

PAIN TYPE:
Neuropathic Pain, Psychological/Comorbidities


2023 Aug 11


Anesthesiology


37566700

Contribution of µ opioid receptor-expressing dorsal horn interneurons to neuropathic pain-like behavior in mice.

Authors

Qi Y, Nelson TS, Prasoon P, Norris C, Taylor BK

Abstract

Intersectional genetics have yielded tremendous advances in our understanding of molecularly-identified subpopulations and circuits within the dorsal horn in neuropathic pain. We tested the hypothesis that spinal µ opioid receptor-expressing interneurons (Oprm1-INs) contribute to behavioral hypersensitivity and neuronal sensitization in the spared nerve injury model in mice.