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Papers of the Week
Contribution of µ opioid receptor-expressing dorsal horn interneurons to neuropathic pain-like behavior in mice.
Authors
Qi Y, Nelson TS, Prasoon P, Norris C, Taylor BKAbstract
Intersectional genetics have yielded tremendous advances in our understanding of molecularly-identified subpopulations and circuits within the dorsal horn in neuropathic pain. We tested the hypothesis that spinal µ opioid receptor-expressing interneurons (Oprm1-INs) contribute to behavioral hypersensitivity and neuronal sensitization in the spared nerve injury model in mice.