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Papers of the Week

Papers: 24 Jun 2023 - 30 Jun 2023

Basic Science

Animal Studies, Genetics, In Silico Studies, Molecular/Cellular, Pharmacology/Drug Development

2023 Jun 19

Br J Pharmacol


Conserved transcriptional programming across sex and species after peripheral nerve injury predicts treatments for neuropathic pain.


Ghazisaeidi S, Muley MM, Tu YS, Finn DP, Kolahdouzan M, Pitcher GM, Kim D, Sengar AS, Ramani AK, Brudno M, Salter MW


Chronic pain is a devastating problem affecting 1 in 5 individuals around the globe, with neuropathic pain the most debilitating and poorly treated type of chronic pain. Advances in transcriptomics have contributed to cataloging diverse cellular pathways and transcriptomic alterations in response to peripheral nerve injury but have focused on phenomenology and classifying transcriptomic responses.