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Papers of the Week


Papers: 24 Jun 2023 - 30 Jun 2023

RESEARCH TYPE:
Basic Science


Animal Studies, Genetics, In Silico Studies, Molecular/Cellular, Pharmacology/Drug Development


2023 Jun 19


Br J Pharmacol


37336547

Conserved transcriptional programming across sex and species after peripheral nerve injury predicts treatments for neuropathic pain.

Authors

Ghazisaeidi S, Muley MM, Tu YS, Finn DP, Kolahdouzan M, Pitcher GM, Kim D, Sengar AS, Ramani AK, Brudno M, Salter MW

Abstract

Chronic pain is a devastating problem affecting 1 in 5 individuals around the globe, with neuropathic pain the most debilitating and poorly treated type of chronic pain. Advances in transcriptomics have contributed to cataloging diverse cellular pathways and transcriptomic alterations in response to peripheral nerve injury but have focused on phenomenology and classifying transcriptomic responses.