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Papers of the Week

Papers: 25 May 2024 - 31 May 2024


Front Comput Neurosci



Computational modeling to study the impact of changes in Nav1.8 sodium channel on neuropathic pain.


Kan P, Zhu YF, Ma J, Singh G


Nav1.8 expression is restricted to sensory neurons; it was hypothesized that aberrant expression and function of this channel at the site of injury contributed to pathological pain. However, the specific contributions of Nav1.8 to neuropathic pain are not as clear as its role in inflammatory pain. The aim of this study is to understand how Nav1.8 present in peripheral sensory neurons regulate neuronal excitability and induce various electrophysiological features on neuropathic pain.