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Papers of the Week

Papers: 16 Sep 2023 - 22 Sep 2023

Basic Science, Clinical

Human Studies, Molecular/Cellular, Neurobiology, Pharmacology/Drug Development

Acute Pain, Inflammation/Inflammatory

2023 Sep 15

J Rheumatol


Complement proteins L-ficolin and M-ficolin are increased in axial spondyloarthritis patients and decrease after TNF-inhibitor treatment.


Mistegaard CE, Troldborg A, Hansen A, Thiel S, Jurik AG, Kiil RM, Christiansen AA, Schiøttz-Christensen B, Hendricks O, Pedersen SJ, Sørensen IJ, Østergaard M, Loft AG


We have previously reported elevated levels of the complement lectin pathway proteins L-ficolin and H-ficolin in axial spondyloarthritis (axSpA) patients compared with healthy controls. The aim of this study was to investigate these biomarkers in a cross-sectional cohort of patients suffering from low back pain (LBP). Furthermore, we aimed to investigate changes in lectin pathway protein levels after initiation of adalimumab (TNF-inhibitor) in a longitudinal cohort of axSpA patients.