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Papers of the Week
Comparison of gepant effects at therapeutic plasma concentrations: connecting pharmacodynamics and pharmacokinetics.
Authors
Boucherie DM, Dammers R, Vincent A, Danser AHJ, MaassenVanDenBrink AAbstract
Orally administered second-generation gepants are effective for the treatment of migraine. The intranasal administration of the third-generation gepant zavegepant might have additional benefits including a rapid onset of action, but it is not clear yet to which extent this has clinical relevance.