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Comparative benefits and harms of perioperative interventions to prevent chronic pain after orthopedic surgery: a systematic review and network meta-analysis of randomized trials.
Authors
Al-Asadi M, Torabiardakani K, Darzi AJ, Gilron I, Marcucci M, Khan JS, Chaparro LE, Rosenbloom BN, Couban RJ, Thomas A, Busse JW, Sadeghirad BAbstract
Chronic postsurgical pain (CPSP) is common following musculoskeletal and orthopedic surgeries and is associated with impairment and reduced quality of life. Several interventions have been proposed to reduce CPSP; however, there remains uncertainty regarding which, if any, are most effective. We will perform a systematic review and network meta-analysis of randomised trials to assess the comparative benefits and harms of perioperative pharmacological and psychological interventions directed at preventing chronic pain after musculoskeletal and orthopedic surgeries.