I am a
Home I AM A Search Login

Papers of the Week

Papers: 24 Jun 2023 - 30 Jun 2023

Basic Science, Methodology

Neurobiology, Neuromodulation

Neuropathic Pain


Front Neurosci



Combined optogenetic and electrical stimulation of the sciatic nerve for selective control of sensory fibers.


Matarazzo JV, Ajay EA, Payne SC, Trang EP, Thompson AC, Marroquin JB, Wise AK, Fallon JB, Richardson RT


Electrical stimulation offers a drug-free alternative for the treatment of many neurological conditions, such as chronic pain. However, it is not easy to selectively activate afferent or efferent fibers of mixed nerves, nor their functional subtypes. Optogenetics overcomes these issues by controlling activity selectively in genetically modified fibers, however the reliability of responses to light are poor compared to electrical stimulation and the high intensities of light required present considerable translational challenges. In this study we employed a combined protocol of optical and electrical stimulation to the sciatic nerve in an optogenetic mouse model to allow for better selectivity, efficiency, and safety to overcome fundamental limitations of electrical-only and optical-only stimulation.