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Papers of the Week
Combined effects of cannabidiol and Δ9-tetrahydrocannabinol alleviate migraine-like symptoms in mice.
Authors
Zorrilla E, Krivoshein G, Kuburas A, Schenke M, Piña CL, van Heiningen SH, Waite JS, Dehghani A, Castonguay WC, Flinn HC, van den Maagdenberg AMJM, Russo AF, Tolner EA, Wattiez ASAbstract
The therapeutic use of cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) to treat migraine has been understudied. Using three mouse models, we examined the impact of CBD and THC on migraine-relevant behaviors triggered by: 1) calcitonin gene-related peptide (CGRP), 2) sodium nitroprusside (SNP), and 3) cortical spreading depolarization (CSD).