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Papers of the Week

Papers: 2 Dec 2023 - 8 Dec 2023

2023 Dec 07

Clin J Gastroenterol


Colitis induced by IL-17A-inhibitors.


Grümme L, Dombret S, Knösel T, Skapenko A, Schulze-Koops H


Interleukin (IL)-17A is essential for intestinal mucosal integrity, contributing to the prevention of detrimental immunity such as infectious colitis and inflammatory bowel disease (IBD). Indeed, neutralization of IL-17A has been abandoned as a therapeutic principle in IBD because of increased disease activity. However, it is controversial whether IL-17A inhibitors increase the risk of developing colitis in patients who do not have underlying IBD. Here, we present two cases of different forms of colitis that occurred during treatment with two IL-17A inhibitors, secukinumab and ixekizumab.