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Papers of the Week
Co-Administration of nalbuphine to improve morphine tolerance in mice with bone cancer pain.
Authors
Ren B, Zhang J, Yang X, Sun D, Sheng D, Fang Q, Ji ZAbstract
Kappa-opioid receptor (KOR) agonists are known for having opposite and/or different effects compared with Mu-opioid receptor (MOR) agonists. This study is aimed at clarifying the analgesic effect and tolerance of nalbuphine combined with morphine, and quantifying the mRNA and protein expression of spinal MOR and KOR in a mouse bone cancer pain (BCP) model treated with nalbuphine and morphine.