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Cluster headache polygenetic risk and known functional variants of CYP3A4 do not associate with treatment response.
Authors
Petersen AS, Barloese M, Lund N, Pedersen AF, Søborg MK, Chalmer MA, Callesen I, Winsvold BS, Zwart JA, , Ostrowski SR, Pedersen OB, Sellebjerg F, Søndergaard HB, Hansen MB, Jensen RH, Hansen TFAbstract
The response to cluster headache treatments has a high interindividual variation. To date, treatment response has only been assessed by candidate gene approach and no investigations into metabolic pathways have been performed. To investigate the association between polygenetic risk of cluster headache and treatment response to first line cluster headache treatments as well as known functional variants of CYP3A4 and the response to verapamil. Further, to replicate previous single nucleotide polymorphisms found to be associated with treatment response in cluster headache and/or migraine.