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Papers of the Week

Papers: 23 Mar 2024 - 29 Mar 2024

2024 Mar 26

J Pharm Pharmacol


Ciprofol alleviates remifentanil-induced hyperalgesia by regulating α2GABAARs, NR2B, and P-CaMKIIα levels in the spinal cord and hippocampus.


Yang Y, Yang C, Shi Y, Tang C, Wang H, Tan M, Xing R, Gao C, Zhang M, Xie Y


Several studies have shown that propofol administration during surgery effectively attenuates remifentanil-induced hyperalgesia (RIH). Ciprofol, a novel intravenous sedative agent analogous to propofol, has not yet been proven efficacious in alleviating RIH. The present study aimed to investigate the effect of ciprofol on RIH and the possible mechanisms involved.