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Papers of the Week


Papers: 25 Mar 2023 - 31 Mar 2023

RESEARCH TYPE:
Review


Molecular/Cellular, Neurobiology

PAIN TYPE:
Psychological/Comorbidities


2023 Mar 11


Int J Mol Sci


36982464


24


6

Chronic Pain-Associated Cardiovascular Disease: The Role of Sympathetic Nerve Activity.

Authors

Reynolds CA, Minic Z

Abstract

Chronic pain affects many people world-wide, and this number is continuously increasing. There is a clear link between chronic pain and the development of cardiovascular disease through activation of the sympathetic nervous system. The purpose of this review is to provide evidence from the literature that highlights the direct relationship between sympathetic nervous system dysfunction and chronic pain. We hypothesize that maladaptive changes within a common neural network regulating the sympathetic nervous system and pain perception contribute to sympathetic overactivation and cardiovascular disease in the setting of chronic pain. We review clinical evidence and highlight the basic neurocircuitry linking the sympathetic and nociceptive networks and the overlap between the neural networks controlling the two.