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Papers of the Week
Characterisation of MRGPRX2 mast cells in irritable bowel syndrome.
Authors
Decraecker L, Cuende Estévez M, Van Remoortel S, Quan R, Stakenborg N, Wang Z, De Marco E, Denadai-Souza A, Viola MF, Garcia Caraballo S, Brierley S, Tsukimi Y, Hicks G, Winchester W, Wykosky J, Fanjul A, Gibson T, Wouters M, Vanden Berghe P, Hussein H, Boeckxstaens GAbstract
Mast cell activation is an important driver of abdominal pain in irritable bowel syndrome (IBS). While evidence supports the role of IgE-mediated mast cell activation in visceral pain development in IBS, the role of pseudoallergic MRGPRX2-mediated mast cell activation in this process remains unknown.