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Papers of the Week


Papers: 27 Apr 2024 - 3 May 2024


2024 Apr 18


J Integr Neurosci


38682225


23


4

Changes in SLITRK1 Level in the Amygdala Mediate Chronic Neuropathic Pain-Induced Anxio-Depressive Behaviors in Mice.

Authors

Chu R, Lu Y, Fan X, Lai C, Li J, Yang R, Xiang Z, Han C, Tian M, Yuan H

Abstract

Comorbid chronic neuropathic pain (NPP) and anxio-depressive disorders (ADD) have become a serious global public-health problem. The SLIT and NTRK-like 1 (SLITRK1) protein is important for synaptic remodeling and is highly expressed in the amygdala, an important brain region involved in various emotional behaviors. We examined whether SLITRK1 protein in the amygdala participates in NPP and comorbid ADD.