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Papers of the Week

Papers: 27 Apr 2024 - 3 May 2024

2024 Apr 18

J Integr Neurosci




Changes in SLITRK1 Level in the Amygdala Mediate Chronic Neuropathic Pain-Induced Anxio-Depressive Behaviors in Mice.


Chu R, Lu Y, Fan X, Lai C, Li J, Yang R, Xiang Z, Han C, Tian M, Yuan H


Comorbid chronic neuropathic pain (NPP) and anxio-depressive disorders (ADD) have become a serious global public-health problem. The SLIT and NTRK-like 1 (SLITRK1) protein is important for synaptic remodeling and is highly expressed in the amygdala, an important brain region involved in various emotional behaviors. We examined whether SLITRK1 protein in the amygdala participates in NPP and comorbid ADD.