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Papers of the Week

Papers: 18 Nov 2023 - 24 Nov 2023

2023 Nov 20

Eur J Pain


CFA-treated mice induce hyperalgesia in healthy mice via an olfactory mechanism.


Zhang Y, Luo W, Heinricher MM, Ryabinin AE


Social interactions with subjects experiencing pain can increase nociceptive sensitivity in observers, even without direct physical contact. In previous experiments, extended indirect exposure to soiled bedding from mice with alcohol withdrawal-related hyperalgesia enhanced nociception in their conspecifics. This finding suggested that olfactory cues could be sufficient for nociceptive hypersensitivity in otherwise untreated animals (also known as “bystanders”).