Celecoxib alleviates nociceptor sensitization mediated by interleukin-1beta-primed annulus fibrosus cells.
Authors
Ma J, Häne S, Eglauf J, Pfannkuche J, Soubrier A, Li Z, Peroglio M, Hoppe S, Benneker L, Lang G, Wangler S, Alini M, Creemers LB, Grad S, Häckel S
Abstract
This study aims to analyze the effect of pro-inflammatory cytokine-stimulated human annulus fibrosus cells (hAFCs) on the sensitization of dorsal root ganglion (DRG) cells. We further hypothesized that celecoxib (cxb) could inhibit hAFCs-induced DRG sensitization.
