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Papers of the Week

Papers: 7 Oct 2023 - 13 Oct 2023

2023 Oct 04

Osteoarthritis Cartilage


CCR2 monocytes as therapeutic targets for acute disc herniation and radiculopathy in mouse models.


Jin L, Xiao L, Manley BJ, Oh EG, Huang W, Zhang Y, Chi J, Shi W, Kerrigan JR, Sung SJ, Kuan CY, Li X


Back pain and radiculopathy caused by disc herniation are major health issues worldwide. While macrophages are key players in disc herniation induced inflammation, their roles and origin in disease progression remain unclear. We aim to study the roles of monocytes and derivatives in a mouse model of disc herniation.