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Papers: 29 Jun 2024 - 5 Jul 2024

2024 Jul 01

Expert Rev Hematol


Can we use biomarkers to identify those at risk of acute pain from sickle cell disease?


Bhat V, Sheehan VA


Acute pain episodes, also known as vaso-occlusive crises (VOC), are a major symptom of sickle cell disease (SCD) and lead to frequent hospitalizations. The diagnosis of VOC can be challenging, particularly in adults with SCD, 50% of whom have chronic pain. Several potential biomarkers have been proposed for identifying individuals with VOC, including elevation above the baseline of various vascular growth factors, cytokines, and other markers of inflammation. However, none have been validated to date.