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Papers of the Week

Papers: 20 Jan 2024 - 26 Jan 2024

2024 Jan 19

J Headache Pain




Calcitonin gene-related peptide antagonists in pregnancy: a disproportionality analysis in VigiBase.


Noseda R, Bedussi F, Gobbi C, Ceschi A, Zecca C


Current evidence on the safety of calcitonin gene-related peptide antagonists (CGRP-A) in pregnancy for the treatment of both episodic and chronic migraine is scarce and does not yet provide definitive information. By querying VigiBase, the World Health Organization global pharmacovigilance database, this study aimed to detect differences in the reporting frequency between CGRP-A and triptans in relation to pregnancy.