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Papers of the Week


Papers: 11 Jan 2025 - 17 Jan 2025


2025 Jan


CNS Neurosci Ther


39801259


31


1

C3/C3aR Bridges Spinal Astrocyte-Microglia Crosstalk and Accelerates Neuroinflammation in Morphine-Tolerant Rats.

Authors

Peng X, Ju J, Li Z, Liu J, Jia X, Wang J, Ren J, Gao F

Abstract

Communication within glial cells acts as a pivotal intermediary factor in modulating neuroimmune pathology. Meanwhile, an increasing awareness has emerged regarding the detrimental role of glial cells and neuroinflammation in morphine tolerance (MT). This study investigated the influence of crosstalk between astrocyte and microglia on the evolution of morphine tolerance.