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Papers of the Week

Papers: 23 Mar 2024 - 29 Mar 2024

2024 Mar 20

J Integr Neurosci




Blocking Pannexin 1 Channels Alleviates Peripheral Inflammatory Pain but not Paclitaxel-Induced Neuropathy.


Lemes JBP, Malange KF, Carvalho NS, Neves AF, Urban-Maldonado M, Kempe PRG, Nishijima CM, Fagundes CC, Lotufo CMDC, Suadicani SO, Parada CA


Pannexin1 (Panx1) is a membrane channel expressed in different cells of the nervous system and is involved in several pathological conditions, including pain and inflammation. At the central nervous system, the role of Panx1 is already well-established. However, in the periphery, there is a lack of information regarding the participation of Panx1 in neuronal sensitization. The dorsal root ganglion (DRG) is a critical structure for pain processing and modulation. For this reason, understanding the molecular mechanism in the DRG associated with neuronal hypersensitivity has become highly relevant to discovering new possibilities for pain treatment. Here, we aimed to investigate the role of Panx1 in acute nociception and peripheral inflammatory and neuropathic pain by using two different approaches.