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Papers of the Week
Blockade of IgG Fc receptors reduces pain after intervertebral disc injury.
Authors
Shi X, Sahbaie P, Guo TZ, Hsu YM, Kingery WS, Clark JDAbstract
Intervertebral disc (IVD) injury is a common cause of low back pain and disability. Recent evidence suggests that autoantibodies contribute to such pain. We, therefore, explored the hypothesis that a novel IgG Fc receptor blocker could reverse chronic pain-related behaviors in a mouse model of IVD injury.