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Papers of the Week

Papers: 18 Nov 2023 - 24 Nov 2023

2023 Nov 17

J Med Chem


Beware the Receptor Variants.


Hanson J


The MAS-related genes (also known as MRGPRs) are a complex family of G protein-coupled receptors initially discovered in sensory neurons. Most of them are orphans, which means that they have no known validated endogenous ligands. Although MRGPRs bear great potential as drug targets, notably in itch and nociception, their study has been hampered by the scarcity or absence of potent and selective ligands, especially for the primate-specific MRGPRX subfamily.