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Papers of the Week

Papers: 15 Jun 2024 - 21 Jun 2024

2024 Jun 15

Arthritis Res Ther




Baricitinib ameliorates inflammatory and neuropathic pain in collagen antibody-induced arthritis mice by modulating the IL-6/JAK/STAT3 pathway and CSF-1 expression in dorsal root ganglion neurons.


Makabe K, Okada H, Tachibana N, Ishikura H, Ito N, Tanaka M, Chijimatsu R, Terashima A, Yano F, Asaka M, Yanagihara D, Taketomi S, Matsumoto T, Tanaka S, Omata Y, Saito T


Janus kinase (JAK) inhibitors, such as baricitinib, are widely used to treat rheumatoid arthritis (RA). Clinical studies show that baricitinib is more effective at reducing pain than other similar drugs. Here, we aimed to elucidate the molecular mechanisms underlying the pain relief conferred by baricitinib, using a mouse model of arthritis.