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Papers of the Week
Baricitinib ameliorates inflammatory and neuropathic pain in collagen antibody-induced arthritis mice by modulating the IL-6/JAK/STAT3 pathway and CSF-1 expression in dorsal root ganglion neurons.
Authors
Makabe K, Okada H, Tachibana N, Ishikura H, Ito N, Tanaka M, Chijimatsu R, Terashima A, Yano F, Asaka M, Yanagihara D, Taketomi S, Matsumoto T, Tanaka S, Omata Y, Saito TAbstract
Janus kinase (JAK) inhibitors, such as baricitinib, are widely used to treat rheumatoid arthritis (RA). Clinical studies show that baricitinib is more effective at reducing pain than other similar drugs. Here, we aimed to elucidate the molecular mechanisms underlying the pain relief conferred by baricitinib, using a mouse model of arthritis.