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Papers of the Week

Papers: 9 Mar 2024 - 15 Mar 2024

2024 Mar 13

Inflamm Bowel Dis


Attenuation of Colitis-Induced Visceral Hypersensitivity and Pain by Selective Silencing of TRPV1-Expressing Fibers in Rat Colon.


Mazor Y, Engelmayer N, Nashashibi H, Rottenfußer L, Lev S, Binshtok AM


Transient receptor potential vanilloid 1 (TRPV1) cation channels, expressed on nociceptors, are well established as key contributors to abdominal pain in inflammatory bowel disease (IBD). Previous attempts at blocking these channels have been riddled with side effects. Here, we propose a novel treatment strategy, utilizing the large pore of TRPV1 channels as a drug delivery system to selectively inhibit visceral nociceptors.