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Papers of the Week

Papers: 17 Feb 2024 - 23 Feb 2024

2024 Feb 15

J Invest Dermatol


Atopic Dermatitis Itch: Scratching for an Explanation.


Biazus Soares G, Hashimoto T, Yosipovitch G


Chronic pruritus is a cardinal symptom of atopic dermatitis (AD). The mechanisms underlying atopic itch involve intricate crosstalk among skin, immune components, and neural components. In this review, we explore these mechanisms, focusing on key players and interactions that induce and exacerbate itch. We discuss the similarities and differences between pruritus and pain in patients with AD as well as the relationship between pruritus and factors such as sweat and the skin microbiome. Furthermore, we explore novel targets that could provide significant itch relief in these patients as well as exciting future research directions to better understand atopic pruritus in darker skin types.