I am a
Home I AM A Search Login

Papers of the Week

Papers: 15 Jun 2024 - 21 Jun 2024

2024 Jun 13




Associations between sickness behavior, but not inflammatory cytokines, and psychiatric comorbidity in chronic pain.


Åström Reitan JLM, Karshikoff B, Holmström L, Lekander M, Kemani MK, Wicksell RK


Approximately one in five adults experiences chronic pain, often in co-occurrence with depression, insomnia, anxiety, and lower self-rated health. Elevated levels of cytokines, e.g. tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), interleukin 8 (IL-8), and interleukin 10 (IL-10), have been identified in patients with chronic pain. Depression, insufficient sleep, poor self-rated health, and pain intensity have also been associated with inflammatory biomarkers. This study aimed to investigate the interrelationships between inflammatory biomarkers and depression, insomnia, anxiety, self-rated health, sickness behavior, and pain intensity in patients with chronic pain.