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Papers of the Week
Association of OPRM1, MIR23B, and MIR107 and genetic variability with acute pain, chronic pain and adverse effects after postoperative tramadol and paracetamol treatment in breast cancer.
Authors
Vidic Z, Goricar K, Strazisar B, Besic N, Dolzan VAbstract
Tramadol is an opioid analgesic often used for pain management after breast cancer surgery. Its analgesic activity is due to the activation of the μ-opioid receptor, encoded by the gene. This study investigated the association of genetic variability in and its regulatory miRNA genes with outcomes of tramadol/paracetamol treatment after breast cancer surgery with axillary lymphadenectomy.