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Papers of the Week


Papers: 18 Jan 2025 - 24 Jan 2025


2024


Front Genet


39831202


15

Association between METTL14 gene polymorphisms and risk of ovarian endometriosis.

Authors

Zhou Z, Jie Y, Hu X, Chen G, Bao Y, OuYang Z, Wu L, Gao T, Zhang Q, Hua W

Abstract

Endometriosis, a prevalent chronic gynecological condition, is frequently associated with infertility and pelvic pain. Despite numerous studies indicating a correlation between epigenetic regulation and endometriosis, its precise genetic etiology remains elusive. Methyltransferase-like 14 (METTL14), a crucial component of the N6-methyladenosine (mA) RNA methyltransferase complex and an RNA binding scaffold, is known to play a pivotal role in various human diseases. The possibility that single nucleotide polymorphisms (SNPs) in the METTL14 gene contribute to susceptibility of endometriosis has not been thoroughly investigated.