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Papers of the Week


Papers: 25 Jan 2025 - 31 Jan 2025


2025 Jan 28


Inflamm Res


39870819


74


1

ASIC1a mediated nucleus pulposus cells pyroptosis and glycolytic crosstalk as a molecular basis for intervertebral disc degeneration.

Authors

Song C, Liu F, Wu X, Zhou D, Mei Y, Wei Z, Shi H, Zeng L, Chen F, Jiang F, Liu Z

Abstract

One of the etiologic components of degenerative spinal illnesses is intervertebral disc degeneration (IVDD), and the accompanying lower back pain is progressively turning into a significant public health problem. Important pathologic characteristics of IVDD include inflammation and acidic microenvironment, albeit it is unclear how these factors contribute to the disease.