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Papers of the Week
Aromatase inhibitors in the pharmacotherapy of endometriosis.
Authors
Gardella B, Rispoli E, Pasquali MF, Mauri M, Musacchi V, Dominoni MAbstract
Endometriosis is a benign chronic inflammatory disease responsible for debilitating pain and decreased quality of life. The traditional treatment is based on estroprogestins, progestins, GnRH analogues and surgery. Recently aromatase inhibitors (AIs) demonstrated good efficacy in controlling symptoms and size of endometriotic implants, mostly because they suppress extraovarian estrogen synthesis, which can enhance the hypoestrogenic state ameliorating symptoms of endometriosis.