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Papers of the Week
AR regulate inflammation through PKA/NF-κB signaling pathways in intervertebral disc degeneration.
Authors
Liu W, Li Q, Fang W, Cai L, Wang Z, Kou B, Zhou C, Zhou Y, Yao Z, Wei M, Zhang SAbstract
Reduction of inflammatory damage and inhibition of nucleus pulposus (NP) apoptosis are considered to be the main effective therapy idea to reverse the intervertebral disc degeneration (IDD) and alleviate the chronic low back pain. The adenosine A2A receptor (A2AR), as a member of G protein-coupled receptor families, plays an important role in the anti-inflammation and relieving pain. So far, the impact of A2AR on IDD therapy is unclear. The aim of this study was to explore the role of Adenosine A receptor (AR) in the intervertebral disc degeneration (IDD) and clarify potential mechanism.