I am a
Home I AM A Search Login

Papers of the Week

Papers: 25 Mar 2023 - 31 Mar 2023


Pharmacology/Drug Development

2023 Mar 24

Anesth Analg


Analgesic Effect of Buprenorphine for Chronic Noncancer Pain: A Systematic Review and Meta-analysis of Randomized Controlled Trials.


Wong SSC, Chan TH, Wang F, Chan TCW, Ho HC, Cheung CW


Buprenorphine is a partial agonist at the µ-opioid receptor and an antagonist at the delta and kappa opioid receptors. It has high affinity and low intrinsic activity at the µ-opioid receptor. Buprenorphine demonstrates no ceiling effect for clinical analgesia, but demonstrates this for respiratory depression and euphoria. It may provide effective analgesia while producing less adverse effects, making it a promising opioid analgesic. A systematic review and meta-analysis were performed to examine the analgesic efficacy of buprenorphine for patients with chronic noncancer pain.