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Papers of the Week

Papers: 30 Dec 2023 - 5 Jan 2024

2023 Dec 29

Br J Pharmacol


An orally available N-type calcium channel inhibitor for the treatment of neuropathic pain.


Kutzsche J, Guzman GA, Willuweit A, Kletke O, Wollert E, Gering I, Jürgens D, Breitkreutz J, Stark H, Beck-Sickinge AG, Klöcker N, Hidalgo P, Willbold D


Neuropathic pain (NP) affects up to 10 % of the global population and is caused by an injury or a disease affecting the somatosensory, peripheral, or central nervous system. NP is characterized by chronic, severe, and opioid-resistant properties. Therefore, its clinical management remains very challenging. The N-type voltage-gated calcium channel Ca 2.2 is a validated target for therapeutic intervention in chronic and neuropathic pain. The conotoxin Prialt is an FDA-approved drug that blocks Ca 2.2 channel but needs to be administered intrathecally. Thus, although being principally efficient, the required application route is very much in disfavor.