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Papers of the Week
An innovative phase 2 chronic pain master protocol design to assess novel mechanisms in multiple pain types.
Authors
Knopp KL, Downing AM, Anthony L, Chaterjee S, Price K, Sparks JAbstract
The phase 2 chronic pain master protocol (CPMP) presented here provides a construct to accelerate the investigation of novel analgesics, broadly referred to here as mechanisms. Designed to address historical challenges in analgesic research and development, such as the choice of indication, this protocol enables the efficient evaluation of potential therapeutics with different mechanisms of action in 3 pain types: nociceptive pain (osteoarthritis), neuropathic pain (diabetic peripheral neuropathic pain), and mixed pain (chronic low back pain).