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Papers of the Week


Papers: 21 Oct 2023 - 27 Oct 2023


2023 Oct 19


Cell Rep


37862165


42


10

An atlas of itch-associated neural dynamics in the mouse brain.

Authors

Chen WZ, Shen TY, Wang M, Yuan L, Wang LH, Ding WQ, Shi XX, Wang XF, Bo BS, Liang ZF, Sun YG

Abstract

The itch-scratching cycle is mediated by neural dynamics in the brain. However, our understanding of the neural dynamics during this cycle remains limited. In this study, we examine the neural dynamics of 126 mouse brain areas by measuring the calcium signal using fiber photometry. We present numerous response patterns in the mouse brain during the itch-scratching cycle. Interestingly, we find that a group of brain areas exhibit activation only at the end of histamine-induced scratching behavior. Additionally, several brain areas exhibit transient activation at the onset of scratching induced by chloroquine. Both histamine- and chloroquine-induced itch evoke diverse response patterns across the mouse brain. In summary, our study provides a comprehensive dataset for the diverse activity pattern of mouse brain during the itch-scratching cycle, paving the way for further exploration into the neural mechanisms underlying the itch-scratching cycle.