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Papers of the Week
Amplified gut feelings under inflammation and depressed mood: A randomized fMRI trial on interoceptive pain in healthy volunteers.
Authors
Benson S, Labrenz F, Kotulla S, Brotte L, Rödder P, Tebbe B, Theysohn N, Engler H, Elsenbruch SAbstract
Inflammation and depressed mood constitute clinically relevant vulnerability factors for enhanced interoceptive sensitivity and chronic visceral pain, but their putative interaction remains untested in human mechanistic studies. We tested interaction effects of acute systemic inflammation and sad mood on the expectation and experience of visceral pain by combining experimental endotoxemia with a mood induction paradigm.