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Papers of the Week


Papers: 4 Mar 2023 - 10 Mar 2023

RESEARCH TYPE:
Basic Science


Human Studies, Molecular/Cellular, Neurobiology

PAIN TYPE:
Psychological/Comorbidities


2023 Mar 07


Sleep


36881901

Alterations of pain pathways by experimental sleep disturbances in humans: Central pain-inhibitory, cyclooxygenase, and endocannabinoid pathways.

Authors

Haack M, Engert LC, Besedovsky L, Goldstein MR, Devine JK, Dang R, Olia K, Molina V, Bertisch SM, Sethna N, Simpson N

Abstract

There is strong evidence that sleep disturbances are an independent risk factor for the development of chronic pain conditions. The mechanisms underlying this association, however, are still not well understood. We examined the effect of experimental sleep disturbances on three pathways involved in pain initiation/resolution: (1) the central pain-inhibitory pathway, (2) the cyclooxygenase (COX) pathway, and (3) the endocannabinoid (eCB) pathway.