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Papers of the Week

Papers: 24 Jun 2023 - 30 Jun 2023

Basic Science

Molecular/Cellular, Neurobiology, Pharmacology/Drug Development

Abdominal/Pelvic Pain, Inflammation/Inflammatory

2023 Jun 27

Biomater Sci


Aloe-derived nanovesicles attenuate inflammation and enhance tight junction proteins for acute colitis treatment.


Choi SH, Eom JY, Kim HJ, Seo W, Kwun HJ, Kim DK, Kim J, Cho YE


Inflammatory bowel disease (IBD) is a chronic recurrent inflammatory disease of the digestive tract that causes pain and weight loss and also increases the risk of colon cancer. Inspired by the benefits of plant-derived nanovesicles and aloe, we herein report aloe-derived nanovesicles, including aloe vera-derived nanovesicles (VNVs), aloe arborescens-derived nanovesicles (ANVs), and aloe saponaria-derived nanovesicles (SNVs) and evaluate their therapeutic potential and molecular mechanisms in a dextran sulfate sodium (DSS)-induced acute experimental colitis mouse model. Aloe-derived nanovesicles not only facilitate markedly reduced DSS-induced acute colonic inflammation, but also enable the restoration of tight junction (TJ) and adherent junction (AJ) proteins to prevent gut permeability in DSS-induced acute colonic injury. These therapeutic effects are ascribed to the anti-inflammatory and anti-oxidant effects of aloe-derived nanovesicles. Therefore, aloe-derived nanovesicles are a safe treatment option for IBD.