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Papers of the Week
Agonists of the opioid δ-receptor improve irritable bowel syndrome-like symptoms via the central nervous system.
Authors
Yoshioka T, Kimiki S, Yamazaki M, Hamano T, Ou M, Ode Y, Ehara R, Kajino K, Kasai S, Yoshizawa K, Saitoh T, Yamada D, Nagase H, Saitoh AAbstract
Irritable bowel syndrome (IBS) is a common condition that is challenging to treat, and novel drugs are needed for this condition. Previously, a chronic vicarious social defeat stress (cVSDS) mouse model exhibits IBS-like symptoms. Also agonists of the opioid δ-receptor exert anti-stress effects in rodents with minimal adverse effects. Here, we evaluated the effects of δ-receptor agonists on the IBS-like symptoms in cVSDS mice.