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Papers of the Week

Papers: 21 Oct 2023 - 27 Oct 2023

2023 Oct 25



Adverse Childhood Experiences and Primary Headache Disorders: A Systematic Review, Meta-analysis, and Application of a Biological Theory.


Sikorski C, Mavromanoli AC, Manji K, Behzad D, Kreatsoulas C


Headache disorders are among the leading causes of disability worldwide. While an association between adverse childhood experiences and primary headaches has been reported, the pooled magnitude across studies and pathways of the association are unknown. Our objectives were 1) to estimate the pooled effect of ≥1 adverse childhood experience (ACE) on primary headache disorders in adulthood, and 2) test the hypothesis that ACEs categorized as “threat” or “deprivation” have distinct impacts on primary headaches based on a selected theory from our narrative review of how ACEs impact development along the life course.