I am a
Home I AM A Search Login

Papers of the Week

Papers: 20 May 2023 - 26 May 2023


Pharmacology/Drug Development

2023 May 18

Expert Opin Drug Discov


Advances with the discovery and development of novel Sigma 1 receptor antagonists for the management of pain.


Burns M, Guadagnoli N, McCurdy CR


Interest in sigma-1 receptors (S1Rs) has significantly increased in the last 25 years and more recently for their role in pain modulation. S1Rs are novel chaperone proteins that modulate several cellular processes and can modulate the activity of many ion channels and receptors. They are heavily localized in pain pathways, leading to the development of S1R antagonists for pain modulation. Though the exact mechanism by which S1R antagonists act is unclear, there has been marked advances in the preclinical and clinical development of S1R antagonists.