Papers of the Week

Interest in sigma-1 receptors (S1Rs) has significantly increased in the last 25 years and more recently for their role in pain modulation. S1Rs are novel chaperone proteins that modulate several cellular processes and can modulate the activity of many ion channels and receptors. They are heavily localized in pain pathways, leading to the development of S1R antagonists for pain modulation. Though the exact mechanism by which S1R antagonists act is unclear, there has been marked advances in the preclinical and clinical development of S1R antagonists.