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Papers of the Week
Advances in the structural understanding of opioid allostery.
Authors
Ramos-Gonzalez N, Varga BR, Majumdar SAbstract
Activation of the μ opioid receptor (MOR) can give analgesia, but also has dangerous side effects. Drugs that target MOR through an allosteric site, meaning they bind outside of the usual pocket, present a novel mode of receptor activation with different pharmacology relative to orthosteric drugs. Recent structural studies give valuable new information on how allosteric modulators interact with MOR.