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Papers of the Week


Papers: 11 Jan 2025 - 17 Jan 2025


2025 Jan 10


Br J Pharmacol


39797405

Activation of δ-opioid receptors blocks allodynia in a model of headache induced by PACAP.

Authors

Mangutov E, Dripps I, Siegersma K, Zhang Y, Bocian R, Asif S, Halbesma T, Witkowski W, Pradhan AA

Abstract

Pituitary adenylate cyclase activating polypeptide (PACAP) is a human migraine trigger that is being targeted for migraine. The δ-opioid receptor (δ-receptor) is a novel target for the treatment of migraine, but its mechanism remains unclear. The goals of this study were to develop a mouse PACAP-headache model using clinically significant doses of PACAP; determine the effects of δ-receptor activation in this model; and investigate the co-expression of δ-receptors, PACAP and PACAP-PAC1 receptor.