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Papers of the Week
Acid-sensing ion channel 3 is required for agmatine-induced histamine-independent itch in mice.
Authors
Zhou GK, Xu WJ, Lu Y, Zhou Y, Feng CZ, Zhang JT, Sun SY, Wang RM, Liu T, Wu BAbstract
Itch is a common symptom of many skin and systemic diseases. Identifying novel endogenous itch mediators and the downstream signaling pathways involved will contribute to the development of new strategies for the treatment of chronic itch. In the present study, we adopted behavioral testing, patch clamp recording and metabonomics analysis to investigate the role of agmatine in itch and the underlying mechanism.