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Papers of the Week
Acamprosate effect on neuropathic pain in rats: with emphasis on the role of ERK/MAPK pathway and SCN9A sodium channel.
Authors
Abbasi Z, Baluchnejadmojarad T, Roghani M, Susanabadi A, Farbin M, Mehrabi SAbstract
Neuropathic pain is a chronic pain owing to nerve damage or diseases of the central nervous system (CNS). The expression of SCN9A, which encodes the Nav1.7 voltage-gated sodium channel and ERK have been found to change significantly in many cases of neuropathic pain. Here, we investigated effects of acamprosate on neuropathic pain, taking into account the crucial roles of SCN9A, the ERK signaling pathway, and inflammatory markers in a rat model of chronic constriction injury (CCI).